Institute of Bio-Sensing Technology

IBST is an initiative of UWE, Bristol

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SpheroidsSpheroid are aggregates of cells grown in a special conditions that allows one to form spheres of tissue which mimic the organ from which the cells were taken. For example hepatic spheroids will take on many of the functions of the liver including producing bilirubin and developing bile canaliculi. Cardiac spheroids beat like a heart.

These three dimensional tissue constructs are useful models to investigate the toxic effects of compounds. This can be performed through the analysis of the media in which the steroids were grown for direct analysis of the spheroids using microscopy for sensor technology.

Applications for spheroids technology include drug discovery and high throughput screening, toxicity testing and environmental testing. There is high potential for the development of novel bio-sensing applications through integrating with new centre technologies.

Lead researcher: Professor Simon Jackson

For more information about spheroids, please contact us.